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pentobarbital will lower the level or effect of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.pentobarbital will lessen the extent or impact of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers may end up in decreased